Research Highlights

A virus that causes childhood coughs and colds could help in the fight against primary liver cancer. Reovirus stimulates the body’s own immune system to kill off the cancerous cells, researchers from the University of Leeds discovered. In addition, Reovirus is able to kill off the hepatitis C virus – a common cause of primary…
In the last 60 years mankind has come to rely on the wonder-cure of antibiotics to solve a multitude of ills by inhibiting disease-causing bacteria and curing potentially fatal infections. However, misuse of antibiotics can lead to some bacteria becoming immune to the effects of antibiotics, stopping us getting better. This is known as anti-microbial…
A new approach has been developed to combat diseases caused by herpesvirus infections, including everything from cold sores to cancer. Researchers at the University of Leeds have discovered a way to prevent herpesviruses hijacking important pathways in cells which are required for the virus to replicate and cause disease. Read the full press release here…
Researchers at the University of Leeds led by Professors Sheena Radford and Neil Ranson have uncovered new information about the operation of a protein complex called BAM – the beta-barrel assembly machinery – which helps insert other bacterial proteins into the bacteria’s outermost protective layer. Read full press release here Read Lateral opening in the intact…
A research team has discovered that a cell’s protective layer acts like a turnstile, allowing proteins to be exported while preventing them from moving back in. All cells are surrounded by a protective layer – a membrane – which keeps the contents of the cell together and protects it from damage. Read the full press…
Scientists from the University of Leeds have solved a 25-year-old question about how a family of proteins allow bacteria to resist the effects of certain antibiotics. Proteins of the ABC-F protein family are a major source of antibiotic resistance in ‘superbugs’ such as Staphylococcus aureus, a group of bacteria that includes MRSA. The findings provide…
A research team led by the University of Leeds has observed for the first time how HIV and Ebola viruses attach to cells to spread infection. The findings suggest a new way of treating these viruses: instead of destroying the pathogens, introduce a block on how they interact with cells. Read the full press release…
A group of drugs already in everyday use to treat psychosis or depression may also be used to defeat deadly and emerging viruses. Researchers from the University of Leeds found that common drugs in everyday use were successful in preventing a particular virus from infecting cells, by blocking the ion channels that regulate potassium levels…
Scientists at the University of Leeds will run the equivalent of password cracking software to find the chemical keys to defeating the Ebola virus. A team from the University’s schools of Chemistry and Molecular and Cellular Biology have secured a £200,000 grant from the Wellcome Trust to find drugs to cure the disease. Read the…