Dr Qian Wu

Our lab is interested in understanding the molecular mechanism of pathways involved in human DNA damage response and repair. We study DNA double-strand breaks (DSBs), which are the most toxic damages in cells. We use structural biology as the main tool to determine the architecture of large protein assemblies function at the damaged DNA ends. This will enable us to identify suitable targets to develop small molecule compounds or protein peptides that modulate the DNA damage response and repair signalling for future drug discovery and medical applications.