- Emeritus Professor
- Areas of expertise
- Affimer artificial binding proteins; Protein expression and engineering, and directed evolution
Research activity is focussed upon the use of our libraries of Affimer artificial binding proteins, previously called Adhiron. These can replace antibodies for most purposes and are small (ca 100 aa), robust (Tm >80 oC), easy to engineer and produce recombinantly. We use them for biomarker detection in research and biosensors, as tools for in vitor and vivo studies of protein-protein interactions, as therapeutics, and imaging reagents. For example a major current focus is in the area of antimicrobial resistance. The lab is also engaged in enzyme engineering, often interfacing with Affimers.