Dr Anton Calabrese

Anton was awarded a Sir Henry Dale Fellowship by the Wellcome Trust and the Royal Society to study the molecular basis of membrane-less organelle formation in viral factories, and to interrogate how aberrant phase transitions contribute to neurodegenerative disease. To achieve this, Anton’s lab develops and applies a toolkit of structural mass spectrometry methods, reinforced with biochemical, cellular and functional assays. This project focuses on studying the protein TDP-43, which plays a role in in neurodegenerative diseases, including motor neurone disease and dementia, in addition to proteins that form viral replication organelles in Rotavirus-infected cells. The understanding of membrane-less organelle formation afforded by these studies may lead to new treatments for neurodegenerative disease and viral infection.