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Dr Anton Calabrese

Sir Henry Dale Fellow and University Academic Fellow (October 2020 - September 2025)
Biological Sciences
Molecular and Cellular Biology

Anton was awarded a Sir Henry Dale Fellowship by the Wellcome Trust and the Royal Society to study the molecular basis of membrane-less organelle formation in viral factories, and to interrogate how aberrant phase transitions contribute to neurodegenerative disease. To achieve this, Anton’s lab develops and applies a toolkit of structural mass spectrometry methods, reinforced with biochemical, cellular and functional assays. This project focuses on studying the protein TDP-43, which plays a role in in neurodegenerative diseases, including motor neurone disease and dementia, in addition to proteins that form viral replication organelles in Rotavirus-infected cells. The understanding of membrane-less organelle formation afforded by these studies may lead to new treatments for neurodegenerative disease and viral infection.