New insights into β2-microglobulin amyloid aggregation

Astbury researchers at the University of Leeds have used cryoEM to determine the structures of fibrils formed from three different variants under identical conditions in vitro.

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... understanding life in molecular detail

The Astbury Centre is an interdisciplinary research centre that brings together around 400 researchers from across the University to understand the molecular basis of life.

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The Astbury Centre offers opportunities for PhD postgraduate programmes and research fellowships and postdoctoral opportunities.

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The Astbury Centre

The Astbury Centre brings together researchers from across the University – largely from physics, the biological sciences and chemistry – to allow interdisciplinary approaches to be harnessed to understand the molecular basis of life. The Centre has outstanding expertise and research infrastructure in chemical biology, biophysics and all of the major techniques in structural molecular biology. Together, these approaches are combined with analyses of biological function with the ultimate aim of understanding the molecular basis of biological mechanisms in living cells.

The Astbury Centre

Our members address major questions associated with biological mechanisms in areas as diverse as membrane proteins; protein folding and assembly; viruses; and motor proteins. The Astbury Centre hosts 4-year PhD programmes funded by the Wellcome Trust and BBSRC that equip students with the wide range of expertise that may be used to address fundamental biological questions.

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The aggregation of β2-microglobulin (β2m) into amyloid fibrils is associated with human disease, but subtly different variants of β2m are...

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Congratulations to Megan who has recently been promoted to Associate Professor following the completion of her University Academic Fellowship.

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A spin out company called CalTIC has been launched by the University of Leeds and its research partners in Germany...

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The five-year project will lead to a better understanding of fundamental biochemical processes of gene regulation and will identify new...

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