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Glycoscience, the ‘science of carbohydrates’, sits at the crossroads of chemistry, biology and physics, shaping how we understand everything from drug design to new materials. Two new initiatives have recently launched that aim to build the glycoscience momentum both in the UK and across Europe. What is glycoscience? We tend to think of sugars as...
For the first time, scientists at University of Leeds reveal a complex mechanism behind blood clotting. The findings, published in Science Advances, visualise a key component of blood clotting - platelet myosin – and how it is activated. activated. Using the powerful cryo-EM technology imaging equipment housed in the Astbury Biostructure Laboratory here at Leeds, scientists found key...
Researchers at the University of Leeds have uncovered exactly how the breakthrough cardiac therapeutic mavacamten works at a molecular level, providing critical new insight into how excessive heart muscle contraction can be safely regulated in patients with hypertrophic cardiomyopathy (HCM). In a study published in Science Advances, scientists from the Astbury Centre for Structural Molecular Biology and the Leeds Institute of Cardiovascular and Metabolic...
Professor Elton Zeqiraj, Professor of Structural Biology in the Astbury Centre and the School of Molecular and Cellular Biology was honoured with the 2027 Sustained Excellence Award, an award which recognises sustained excellence in research, alongside a strong commitment to developing, supporting and nurturing future talent. Meanwhile Dr. Helen Foster, a Lecturer in Cryo-Electron Tomography,...
Alab-produced antibody technology developed by researchers at Leeds has been recognised in a government strategy for reducing the use of animals in scientific research. Adhirons, referenced in the strategy under their former name, are featured in the Department for Science, Innovation and Technology (DSIT) document, Replacing animals in science: A strategy to support the development, validation and...
New photo-switchable chemical probes allow the precise control of ion channel activity in cells and tissues using different wavelengths of light. A study by a consortium of researchers from Germany and the Astbury Centre demonstrates the concept of ‘ideal efficacy switching’ as an exquisite way to control biological activity. The work, led by Prof. Oliver...
The new awards will provide £3.4 million to support research into life at the molecular level. The awards are also a reflection of the Astbury Centre for Structural Molecular Biology’s reputation for interdisciplinary research and infrastructure. The newly funded teams will benefit from the advanced cryo-electron microscopy (cryoEM) capabilities housed in the Astbury Biostructure...
The Cheney Biomedical Accelerator facility, designed to spark bold, cross-disciplinary discoveries in biomedical and health science, has officially opened at the University of Leeds. The Cheney Biomedical Accelerator brings together the University’s advanced Bioimaging and flow cytometry laboratories, which include a range of different types of high-resolution microscopes and imaging equipment. It will also include...
A previously overlooked type of circular DNA may help explain why some children with leukaemia relapse, according to landmark research from the University of Leeds published in Nature. The research builds on earlier work that linked leukaemia (a type of blood cancer) to excised signal circles (ESCs) - circular forms of DNA that are normally...
Research has revealed how a tick-borne virus manipulates human brain chemistry to survive, offering new hope for diagnosis and treatment. The study found that the tick-borne encephalitis virus (TBEV), a disease transmitted through tick bites or unpasteurised dairy products, alters key molecules in the brain to aid its survival. With symptoms similar to flu, TBEV...