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Scientists discover promising new way to personalise treatment for patients with cancer and autoimmune diseases

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Researchers at the University of Leeds have developed a new diagnostic approach that can quickly identify how a patient is responding to antibody medication. The technology, which uses special sensors called enzyme switch sensors, can detect the amount of therapeutic monoclonal antibodies (TmAb) that are present in a patient’s system. TmAbs are medicines that are...

Britons getting tattoos and cosmetic procedures abroad may be at risk of Hepatitis C – here’s how to avoid it

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Dr Grace Roberts, researcher in the School of Molecular and Cellular Biology, writes for The Conversation. A growing number of people living in the UK are going abroad to have tattoos, piercings and cosmetic surgeries. Any procedure, no matter where it’s performed, can carry the risk of injury and infection. But people heading abroad for cosmetic procedures...

New project launched to accelerate drug discovery

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Researchers from the School of Molecular and Cellular Biology have joined a consortium of academics and industry partners as part of a new 9.7MЄ study. The EU-funded project, Fragment-Screen, which is being led by Instruct-ERIC, aims to develop innovative tools that could help to advance new drugs using the approach of fragment-based drug discovery. A team...

New insights into β2-microglobulin amyloid aggregation

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The aggregation of β2-microglobulin (β2m) into amyloid fibrils is associated with human disease, but subtly different variants of β2m are associated with diseases with distinct pathologies. Astbury researchers at the University of Leeds have used cryoEM to determine the structures of fibrils formed from three different variants under identical conditions in vitro. The research, from...

Molecules could target cardio-metabolic diseases

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A spin out company called CalTIC has been launched by the University of Leeds and its research partners in Germany - the Lead Discovery Centre, a specialist drug discovery laboratory in Dortmund; the Max Planck Society; and Heidelberg University - to commercially exploit the research. Research over the past two decades has culminated in a...

University of Leeds secures £5.6 million grant to understand new layer of gene regulation by ribosomes

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The five-year project will lead to a better understanding of fundamental biochemical processes of gene regulation and will identify new research strategies for tackling cancer and other diseases. Julie Aspden, Associate Professor of RNA at Leeds and principal investigator, said: “The goal of this project is not only to understand how genes are expressed by...

Congratualtions to Professor Lorna Dougan on being awarded the British Biophysical Society Elspeth Garman Prize for Public Engagement

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Professor Lorna Dougan has been awarded the British Biophysical Society Elspeth Garman Prize for Public Engagement for her pioneering work in developing and delivering creative public engagement resources to diverse communities. The prize is awarded every two years and recognises excellence in biological physics engagement. Biophysics is a vibrant scientific field, with world leading activity...

Richard Henderson keynote speaker at the Astbury Conversation 2022

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Richard Henderson – a molecular biologist and biophysicist - was jointly awarded the Nobel Prize in 2017 for developing cryo-electron microscopy techniques to determine in high resolution the structure of important biomolecules.  He delivered the keynote speech at the Astbury Conversation 2022. Professor Simone Buitendijk, Vice-Chancellor of the University of Leeds, said: “It is a...