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Professor Alison Ashcroft

Emeritus Professor
Areas of expertise
mass spectrometry; electrospray ionisation; ion mobility spectrometry; native/biomolecular mass spectrometry; tandem mass spectrometry; FPOP; HDX.

My research is focused on developing and applying mass spectrometric techniques and methodologies to the analysis of biomolecules. Our work uses electrospray ionisation (ESI) non-covalent mass spectrometry (MS) coupled with ion mobility spectrometry (IMS) and thus we are able to measure the molecular mass and size (i.e. cross-sectional area) of individual biomolecules from within highly heterogeneous mixtures in a single experiment. We study protein folding and aggregation and their relevance to protein-related diseases.