New Mass Spectrometry Frontiers

For the first time, academics in the Astbury Centre have recorded the highest mass-to-charge ratios ever measured on an Orbitrap machine. But how did they do it?

A recently developed technique, called electron capture charge reduction, reduces charge in biomolecular structures. It’s now offering huge promise for analysing larger sized proteins – a current limitation of existing mass spectrometry techniques.

Read the blog New Mass Spec Frontiers on science.org.

You can also read the full paper “To 200,000 m/z and Beyond: Native Electron Capture Charge Reduction Mass Spectrometry Deconvolves Heterogeneous Signals in Large Biopharmaceutical Analytes”, in the latest issue of ACS Central Science.