The intricate protein architecture linked to disease

Scientists have for the first time identified the structure of a protein fibre linked to early-onset type 2 diabetes. In research published in the journal Nature Structural and Molecular Biology, scientists at the University of Leeds report that they have been able to visualise the structure of amylin fibrils using the latest electron microscope technology.

Neil Ranson, Professor of Structural Molecular Biology and Deputy Director of the Astbury Centre, said: ““This is just the beginning of the journey to find new ways of combatting amyloid disease and was impossible before the new powerful methods of electron microscopy were developed.”

Read the full press release on the University of Leeds website

Read Fibril structures of diabetes-related amylin variants reveal a basis for surface-templated assembly on the Nature Structural and Molecular Biology website