Results 91 to 100 of 108
Researchers at the University of Leeds led by Professors Sheena Radford and Neil Ranson have uncovered new information about the operation of a protein complex called BAM – the beta-barrel assembly machinery – which helps insert other bacterial proteins into the bacteria’s outermost protective layer. Read full press release here Read Lateral opening in the intact...
A research team has discovered that a cell's protective layer acts like a turnstile, allowing proteins to be exported while preventing them from moving back in. All cells are surrounded by a protective layer – a membrane – which keeps the contents of the cell together and protects it from damage. Read the full press...
Nobel Laureate Professor Michael Levitt is to speak at the University on Tuesday 12 April as part of the first ‘Astbury Conversation’. The Astbury Conversation (11 – 12 April), celebrating advances in molecular biology, also includes a public exhibition, providing a fascinating insight into the complex molecules and chemical reactions that are essential for life....
Scientists from the University of Leeds have solved a 25-year-old question about how a family of proteins allow bacteria to resist the effects of certain antibiotics. Proteins of the ABC-F protein family are a major source of antibiotic resistance in ‘superbugs’ such as Staphylococcus aureus, a group of bacteria that includes MRSA. The findings provide...
A research team led by the University of Leeds has observed for the first time how HIV and Ebola viruses attach to cells to spread infection. The findings suggest a new way of treating these viruses: instead of destroying the pathogens, introduce a block on how they interact with cells. Read the full press release...
A group of drugs already in everyday use to treat psychosis or depression may also be used to defeat deadly and emerging viruses. Researchers from the University of Leeds found that common drugs in everyday use were successful in preventing a particular virus from infecting cells, by blocking the ion channels that regulate potassium levels...
Scientists at the University of Leeds will run the equivalent of password cracking software to find the chemical keys to defeating the Ebola virus. A team from the University’s schools of Chemistry and Molecular and Cellular Biology have secured a £200,000 grant from the Wellcome Trust to find drugs to cure the disease. Read the...
A new £3.4 million programme will develop new tools to understand which interactions between proteins in the human body are relevant to disease. Currently, only a handful of drugs in clinical use work by targeting protein-protein interactions. A new £3.4 million programme will develop new tools to understand which interactions between proteins in the human...
Scientists have developed an innovative way of using one of the biggest problems facing health services—antibiotic resistance—to develop drugs to combat some of the most intractable diseases. Read the full press release here Read An in vivo platform for identifying inhibitors of protein aggregation in Nature Chemical Biology
Understanding how a plant virus assembles could lay the groundwork for future use to carry drugs into the human body. The Nature Communications paper investigates vital steps to understanding how safe, plant-based virus-like particles could be created in the future. Read the full press release here Read Mechanisms of assembly and genome packaging in an RNA...