Results 11 to 20 of 88
Professor Richard Bayliss, School of Molecular and Cellular Biology, and Dr Charlotte Dodson, University of Bath, reflect on what the latest developments in AlphaFold 3 mean for biologists. AlphaFold 3 is the latest version of an algorithm designed to predict the structures of proteins – vital molecules used by all life – from the “instruction code” in...
New research carried out at the University of Leeds, in collaboration with the CRUK Scotland Institute and the University of Cambridge, has led to the discovery of a nanobody that offers a potential new approach for preventing the spread of cancer, known as metastasis. A protein called Fascin-1, which is found at high levels in...
A group of scientists from the University of Leeds and the University of Dundee have discovered new knowledge in how ribosomes – the key machinery that makes proteins for our cells - are rescued. The researchers used an imaging technique called cryo-electron microscopy (cryo-EM) to visualise the 3D structure of UREL bound to the ribosome...
For the first time, an interdisciplinary team of researchers has revealed intricate 3D detail of how the structure of a malfunctioning protein, hIAPP, evolves over time. Scientists used Cryo-Electron Microscopy (cryoEM) – a high resolution imaging technique - to determine the structures of the hIAPP amyloid fibrils present at three distinct points of growth; an...
For the first time, scientists have witnessed new molecular behaviour in proteins that protect us from cancer. Scientists in the have identified new features of BRCA1–BARD1, a group of proteins that play a critical role in repairing damaged DNA. Using ground-breaking imaging techniques, thanks to the state-of-the-art equipment at the Astbury and Bragg centres in...
Researchers at the University of Leeds have developed a new diagnostic approach that can quickly identify how a patient is responding to antibody medication. The technology, which uses special sensors called enzyme switch sensors, can detect the amount of therapeutic monoclonal antibodies (TmAb) that are present in a patient’s system. TmAbs are medicines that are...
Dr Grace Roberts, researcher in the School of Molecular and Cellular Biology, writes for The Conversation. A growing number of people living in the UK are going abroad to have tattoos, piercings and cosmetic surgeries. Any procedure, no matter where it’s performed, can carry the risk of injury and infection. But people heading abroad for cosmetic procedures...
Researchers from the School of Molecular and Cellular Biology have joined a consortium of academics and industry partners as part of a new 9.7MЄ study. The EU-funded project, Fragment-Screen, which is being led by Instruct-ERIC, aims to develop innovative tools that could help to advance new drugs using the approach of fragment-based drug discovery. A team...
The aggregation of β2-microglobulin (β2m) into amyloid fibrils is associated with human disease, but subtly different variants of β2m are associated with diseases with distinct pathologies. Astbury researchers at the University of Leeds have used cryoEM to determine the structures of fibrils formed from three different variants under identical conditions in vitro. The research, from...
The five-year project will lead to a better understanding of fundamental biochemical processes of gene regulation and will identify new research strategies for tackling cancer and other diseases. Julie Aspden, Associate Professor of RNA at Leeds and principal investigator, said: “The goal of this project is not only to understand how genes are expressed by...