Research Highlights

The University of Leeds has secured a £5.4 million grant to identify new techniques for investigating and manipulating the chemical building blocks of life – proteins. The five-year project – in collaboration with the University of Oxford – will lead to a better understanding of fundamental biochemical processes and will identify new research strategies for…
Scientists have for the first time identified the structure of a protein fibre linked to early-onset type 2 diabetes. In research published in the journal Nature Structural and Molecular Biology, scientists at the University of Leeds report that they have been able to visualise the structure of amylin fibrils using the latest electron microscope technology….
Visualising how molecules move in cells or interact with drugs will be possible with one of the world’s most advanced imaging centres being developed at the University. Known as the Wolfson Imaging Facility, it will enable scientists to watch viruses attacking cells, immune cells getting ready to attack their targets and the cellular “railroads” used to transport molecules to their correct destinations….
Scientists have identified a key process in the way bacteria protect themselves from attack – and it heralds a new strategy in the hunt for antibiotics. The researchers from the University of Leeds have pieced together how bacteria build their outer, defensive wall – in essence, the cell’s armour plating. The research team focused on…
Scientists have developed a technique that could significantly reduce the time to discover potential new antibody-based drugs to treat disease. Read the full press release on the University of Leeds website Read An in vivo platform to select and evolve aggregation-resistant proteins on the Nature Comms website
Every picture tells a story… none more so than this detailed visualisation of a strain of the norovirus. Created from 13,000 separate images taken by an electron microscope, it reveals in rich detail the structure of the virus. It shows bump-like protrusions on the outside of the virus capsid, the protein shell that holds the…
A master control region of a protein linked to Parkinson’s disease has been identified for the first time. The finding, made by scientists from the University of Leeds’ Astbury Centre for Structural Molecular Biology, provides a new target for the development of therapies to try and slow down or even prevent the disease. Parkinson’s affects…
The University is to be part of two supercomputing centres – to boost the ability of researchers to make major scientific breakthroughs. The announcement is part of a £27 million investment from the Engineering and Physical Sciences Research Council to ensure academics have access to state-of-the-art, high-performance computing facilities. Dr Sarah Harris, Associate Professor in…
Research which has identified a way of making a safer and cheaper polio vaccine is to be scaled-up – to see if it could be used in commercial vaccine production. The new approach, which has the potential to revolutionise vaccine development across the board, is the result of a scientific collaboration led by the University….
This discovery could lead to photosynthesis being ‘redesigned’ to achieve higher yields and meet urgent food security needs. The research, published in the journal Nature, reveals the structure of cytochrome b6f – the protein complex that significantly influences plant growth via photosynthesis. Using a high-resolution structural model, scientists found that the protein complex provides the electrical connection…