Research Highlights

Scientists have discovered how drug-like small molecules can regulate the activity of therapeutically relevant ion channels – and their findings could transform ongoing drug development efforts. The new study provides detailed insight into the regulation of TRPC5 ion channels, which allow positively charged ions such as calcium, sodium and potassium to flow in and out…
Researchers at the University of Leeds and University of Cambridge demonstrated that tiny gold nanotubes could treat cancer caused by asbestos fibres. In the study, the scientists showed that – when inside cancer cells – the nanotubes can absorb light, which causes them to heat up and kill the cells. The new research may pave…
The University of Leeds has secured a £5.4 million grant to identify new techniques for investigating and manipulating the chemical building blocks of life – proteins. The five-year project – in collaboration with the University of Oxford – will lead to a better understanding of fundamental biochemical processes and will identify new research strategies for…
Scientists have for the first time identified the structure of a protein fibre linked to early-onset type 2 diabetes. In research published in the journal Nature Structural and Molecular Biology, scientists at the University of Leeds report that they have been able to visualise the structure of amylin fibrils using the latest electron microscope technology….
Visualising how molecules move in cells or interact with drugs will be possible with one of the world’s most advanced imaging centres being developed at the University. Known as the Wolfson Imaging Facility, it will enable scientists to watch viruses attacking cells, immune cells getting ready to attack their targets and the cellular “railroads” used to transport molecules to their correct destinations….
Scientists have identified a key process in the way bacteria protect themselves from attack – and it heralds a new strategy in the hunt for antibiotics. The researchers from the University of Leeds have pieced together how bacteria build their outer, defensive wall – in essence, the cell’s armour plating. The research team focused on…
Scientists have developed a technique that could significantly reduce the time to discover potential new antibody-based drugs to treat disease. Read the full press release on the University of Leeds website Read An in vivo platform to select and evolve aggregation-resistant proteins on the Nature Comms website
Every picture tells a story… none more so than this detailed visualisation of a strain of the norovirus. Created from 13,000 separate images taken by an electron microscope, it reveals in rich detail the structure of the virus. It shows bump-like protrusions on the outside of the virus capsid, the protein shell that holds the…
A master control region of a protein linked to Parkinson’s disease has been identified for the first time. The finding, made by scientists from the University of Leeds’ Astbury Centre for Structural Molecular Biology, provides a new target for the development of therapies to try and slow down or even prevent the disease. Parkinson’s affects…
The University is to be part of two supercomputing centres – to boost the ability of researchers to make major scientific breakthroughs. The announcement is part of a £27 million investment from the Engineering and Physical Sciences Research Council to ensure academics have access to state-of-the-art, high-performance computing facilities. Dr Sarah Harris, Associate Professor in…