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Research Professorship to explore how protein interactions shape health

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The UK's leading scientific academy – the Royal Society – has announced that Professor Sheena Radford is to receive one of its most prestigious research awards. The Research Professorship will enable Professor Radford, Director of the Astbury Centre for Structural Molecular Biology, to develop new techniques to "see the unseen" and reveal the way that...

Unravelling the process that makes viruses infectious

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Researchers have for the first time identified the way viruses like the poliovirus and the common cold virus ‘package up’ their genetic code, allowing them to infect cells. Once a cell is infected, a virus needs to spread its genetic material to other cells. This is a complex process involving the creation of what are...

Using targeted microbubbles to administer toxic cancer drugs

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University of Leeds research has shown how microbubbles carrying powerful cancer drugs can be guided to the site of a tumour using antibodies. Microbubbles are small manufactured spheres half the size of a red blood cell - and scientists believe they can be used to transport drugs to highly specific locations within the body. Professor...

How a protein ‘hunkers down’ to conserve energy

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A visualisation made from nearly 100,000 electron microscope images has revealed the ingenious way a protein involved in muscle activity shuts itself down to conserve energy. The protein, called myosin, is known as a molecular motor because of the way it interacts with other proteins and energy molecules to generate force and movement. It is...

Understanding ion channel inhibition to open doors in drug discovery

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Scientists have discovered how drug-like small molecules can regulate the activity of therapeutically relevant ion channels - and their findings could transform ongoing drug development efforts. The new study provides detailed insight into the regulation of TRPC5 ion channels, which allow positively charged ions such as calcium, sodium and potassium to flow in and out...

Gold nanotubes could help treat asbestos cancer

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Researchers at the University of Leeds and University of Cambridge demonstrated that tiny gold nanotubes could treat cancer caused by asbestos fibres. In the study, the scientists showed that – when inside cancer cells – the nanotubes can absorb light, which causes them to heat up and kill the cells. The new research may pave...

Professor Sheena Radford recognised in Queen’s Birthday Honours

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Professor Sheena Radford, the Director of the Astbury Centre for Structural Molecular Biology, has been honoured with an OBE, for her research at the frontiers of molecular biology. As director of the Astbury Centre for Structural Molecular Biology, Professor Sheena Radford has led a large group of researchers investigating the complex molecular basis of life....

Understanding the way proteins shapeshift

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The University of Leeds has secured a £5.4 million grant to identify new techniques for investigating and manipulating the chemical building blocks of life - proteins. The five-year project - in collaboration with the University of Oxford - will lead to a better understanding of fundamental biochemical processes and will identify new research strategies for...