Advanced Mass Spectometry

Application

Non-covalent mass spectrometry for determination of sub unit stoichiometry of proteins and their biomolecular complexes. This can be extended to determine the collisional cross sectional areas using ion mobility spectrometry-MS and to examine shape and conformational changes under different conditions. Hydrogen deuterium exchange-mass spectrometry is available for probing localised changes in protein dynamics and hydrogen bonding in perturbed systems.

Equipment

https://biologicalsciences.leeds.ac.uk/facilities/doc/mass-spectrometry

Contact

mass-spec@leeds.ac.uk